What Is Trans-Resveratrol and What Are the Benefits?

What Is Trans-Resveratrol and What Are the Benefits?

Trans-resveratrol is a powerful form of the naturally occurring polyphenol: resveratrol. It plays an essential role in plant defence as a phytoalexin, protecting against pathogens and environmental stresses.

Found primarily in the skins of grapes, berries, and plants like Japanese Knotweed, trans-resveratrol is linked to various health benefits, often associated with drinking red wine.

Beyond its traditional benefits, trans-resveratrol has practical applications in managing and reducing the risk of neurodegenerative diseases, cardiovascular issues, and certain cancers.

Today, we’ll dive into the sources of trans-resveratrol, unpack its health benefits, and explore why supplementation is crucial to fully harness its therapeutic potential (we’ll also introduce the perfect trans-resveratrol supplement).

What Is Trans-Resveratrol And What Are The Benefits

Trans-resveratrol is the active, bioavailable form of resveratrol [1], a polyphenol known for its antioxidative and anti-inflammatory properties. 

As a phytoalexin, trans-resveratrol acts as a critical defensive substance in plants [2], produced in response to stress, infection, or fungal attack. It works as both a survival mechanism for plants and a source of significant health benefits for humans.

As discussed above, it’s most abundantly found in the skins of red grapes, lending to the health-promoting properties of red wine. 

However, it’s also prevalent in other berries, such as blueberries and raspberries, and in substantial amounts in Japanese Knotweed.

The benefits of trans-resveratrol start with its antioxidant capacity, but it’s increasingly recognized for its potential to improve heart health [3], enhance neurological resilience [4], and reduce the risks of some chronic diseases [5]. 

As research progresses, the list of benefits grows, making trans-resveratrol super important in preventive health strategies. 

Polyphenols, Resveratrol and Their Role in Health

Overview of Polyphenols

Polyphenols are a diverse group of over 8,000 phytochemical compounds found across various plant species, playing critical roles in plant defence against environmental stresses [6]. 

In recent years, the health-promoting properties of polyphenols, including resveratrol and the more potent trans-resveratrol, have garnered attention from medical professionals, nutritionists, and clinical researchers, who advocate for the consumption of polyphenol-rich plant-based foods due to their potent antioxidant, anti-inflammatory, and disease-fighting capabilities. 

In fact, trans-resveratrol comes with a wide array of preventative and therapeutic benefits. This potent polyphenol offers protective and enhancing capabilities in several key areas:

  • Neurodegenerative Diseases: Protects against disorders such as Parkinson’s, Alzheimer’s, and Huntington's by modulating degenerative pathways, protecting neurons, and inhibiting the toxic effects of beta-amyloid proteins. [7]
  • Cardiovascular Health: Enhances heart function, reduces inflammation, and lowers blood pressure. [8]
  • Cancer Prevention: Neutralises free radicals and inhibits tumour growth, particularly in cancers like colon, prostate, and breast cancer. [9]
  • Cholesterol Management: Blocks cholesterol oxidation, reducing LDL levels and lowering cardiovascular risk. [10]
  • Diabetes Management: Protects beta cells from glucose toxicity and improves glycemic control. [11]
  • Obesity Control: Increases fat oxidation, reduces lipogenesis, and boosts energy expenditure, aiding weight loss and maintenance. [12]

These benefits show that regular consumption of trans-resveratrol plays a vital role in preventing and managing chronic diseases, making it a key component of preventive health strategies.

The Scientific Backing: What Studies Say


The health benefits of trans-resveratrol are supported by a strong foundation of scientific research. 

Major Studies and Reviews

A 2018 review by the Harvard T.H. Chan School of Public Health has played a pivotal role in understanding the impact of polyphenols on human health. 

This review confirmed that polyphenols, including trans-resveratrol, significantly contribute to the regulation of metabolism, weight management, and chronic disease prevention.

Emerging Research

Emerging research continues to build on these findings, exploring more in-depth mechanisms through which trans-resveratrol and other polyphenols exert their effects. 

For example, recent studies have delved into the molecular interactions between trans-resveratrol and cellular pathways, showcasing its potential to modulate gene expression and impact cellular ageing processes positively [13]. 

Additionally, ongoing research is investigating the synergy between trans-resveratrol and gut microbiota, which could further define its role in promoting gastrointestinal health and systemic immunity.

Resveratrol and Longer Life

According to a long-term study by Dr. Richard A. Miller of the University of Michigan, trans-resveratrol can mimic the effects of caloric restriction. 

This helps counteract the risks associated with high-calorie diets and plays a key role in life extension. 

By activating biological pathways similar to those triggered by dietary restriction, trans-resveratrol promotes the body’s mechanisms for longevity, offering a practical way to enhance health and potentially increase life span without significant dietary alterations.

The Differences Between Trans-Resveratrol and Resveratrol

Trans-resveratrol and resveratrol are two forms of the same compound, but they differ significantly in their stability and effectiveness. 

Trans-resveratrol is the more bioactive form, meaning it is better absorbed and utilised by the body [14]. This is primarily due to its chemical structure, which allows it to be more stable under various physiological conditions. 

In contrast, resveratrol can exist in both trans and cis forms [15], with the cis form being less stable and less effective.

Here’s a simple table to highlight the key differences:





More stable, retains efficacy longer

Less stable, prone to degradation


Higher, due to better absorption

Lower, due to poor absorption

Biological Activity

Higher, influences more health pathways

Lower, less effective in the body

Trans-resveratrol is simply the active ingredient in resveratrol, which is an important distinction when seeking supplements for maximum efficacy. 

For instance, Love Life Supplements Trans-Resveratrol offers a 98% strength, pure extract from Japanese Knotweed, containing 500mg of Trans-Resveratrol per serving, and nothing else.

However, considering the availability of trans-resveratrol in wine, berries, and fruits, the question arises why supplements are necessary. 

The answer lies in the required dosage levels for health benefits, which are significantly higher than what can be obtained from dietary sources. 

Clinical trials typically start with dosages of 250mg or more, while a glass of red wine contains only about 1mg of trans-resveratrol. 

Consuming 250 glasses of red wine daily is neither practical nor recommended, making a high-quality supplement a far more viable option. This ensures you can achieve the necessary therapeutic doses of trans-resveratrol to harness its full health benefits.

Why Supplements?


While trans-resveratrol is naturally found in foods like grapes, blueberries, and particularly in Japanese Knotweed, achieving the therapeutic doses required for significant health benefits through diet alone is challenging. This is where high-dose supplements become essential.

Trans-resveratrol supplements offer a concentrated form of this potent polyphenol, ensuring that you receive an adequate amount to impact health positively. 

💡Did you know? Japanese Knotweed, a primary source in these supplements, contains high concentrations of trans-resveratrol, which is more stable and bioavailable compared to other forms. This makes it particularly effective for improving cardiovascular health, enhancing cognitive functions, and regulating blood pressure and blood sugar.


When choosing supplements, look for products that specify they contain trans-resveratrol from Japanese Knotweed and ensure the product states the percentage of trans-resveratrol to guarantee potency. 

For example, a high-quality supplement should have at least 98% trans-resveratrol, like those derived purely from Japanese Knotweed root extract, without fillers or flow agents. This ensures you are getting a pure, potent product that maximises the potential health benefits.

These supplements provide a practical means to harness the full spectrum of trans-resveratrol’s benefits, far exceeding what is typically consumed in a standard diet.

Enhancing Your Health Journey with Love Life Supplements


Love Life Supplements offers a practical and effective solution for supplementing with high-quality, high-potency trans-resveratrol supplements derived from Japanese Knotweed.

However, to further support your health journey, we encourage you to explore the wealth of resources available on our website. 

Check out our other informative blog posts to deepen your understanding of health and wellness. Subscribe to our newsletter for the latest updates and insights directly in your inbox. And don't forget to take our personalised quiz to find the perfect supplement tailored to your health needs.

With Love Life Supplements, you're taking a leap towards a healthier, more vibrant life. Explore our options today and find out how our products can support your wellness goals.


[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796143/#:~:text=Resveratrol%20exhibits%20strong%20antioxidant%20activity,signaling%20pathways%20(Figure%203).

[2] [8] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494027/

[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413130/

[4] [7]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571425/

[5] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261232/

[6] https://www.chhs.colostate.edu/krnc/monthly-blog/what-are-polyphenols-another-great-reason-to-eat-fruits-and-veggies/#:~:text=Polyphenols%20are%20a%20class%20of,have%20been%20identified%20so%20far.

[9] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943596/

[10] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026982/

[11] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983094/#:~:text=Resveratrol%20has%20been%20shown%20to%20be%20effective%20in%20modulating%20blood,hypertension%20and%20countering%20odixative%20stress.

[12] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002514/#:~:text=This%20polyphenolic%20compound%20has%20been,4%2C5%2C6%5D.

[13] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587336/#:~:text=Resveratrol%20can%20slow%20the%20aging,%2Finflammation%20(Figure%202).

[14] https://www.sciencedirect.com/topics/chemistry/trans-resveratrol 

[15] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146108/


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