The Definitive Guide To Curcumin

Curcumin C3

Can Curcumin offer you a happy, healthy and pain free body?

In this edition of the LLS blog I would like to turn our attention to Curcumin, a supplement becoming ever popular for its well researched benefits.

What is Curcumin?

If you are not familiar with Curcumin, you may already be consuming it in small doses when you eat your favourite curry. Curcumin is the active ingredient in Turmeric, a perennial plant of the Ginger family where it contributes the yellow pigmentation to Turmeric and Ginger roots.

Tumeric grows in tropical regions of Asia such as India. It has been used as a herbal remedy for numerous years, particularly in Indonesia, India, and China. Curcumin is a traditional Chinese medicine that is used to treat diseases that are associated with abdominal pain. Furthermore, it was originally an ancient Hindu medicine that was used to treat swelling and sprains; there are also several stories that suggest that curcumin was used as far as 10,000 years ago.

What are the benefits of Curcumin?

The 3 main reported benefits for Curcumin C3 are:

  • Antioxidant Effect
  • Anti –Inflammatory Support
  • Immune Support

So let's analyse each benefit in more depth.

Antioxidant Effect

Curcumin can hunt down free radicals and rid them from our bodies and it prevent the formation of free radicals in the first place. A 10 week randomised study set out to observe the effect of Curcumin supplementation on overall oxidative stress and circulating levels of anti-oxLDL and anti-Hsp27 in obese individuals.

The patients were randomised to receive either Curcuminoids (1 g/day) or matched placebo for 30 days. The Curcumin supplementation was associated with a significant reduction in serum PAB (P=0.044) over this time. This is first cross over trial on Curcumin which showed the effect on pro-oxidant – antioxidant status. Also the result of the study shows that Curcumin mitigates oxidative stress. [2]

Another study investigated the efficacy of short-term supplementation with Curcuminoids (plus Piperine for enhanced bioavailability) in alleviating systemic oxidative stress, clinical symptoms and improvement in health related quality of life (HRQoL). This also concluded that Curcumin C3 supplementation was found to mitigate oxidative stress, decreasing symptoms and improving HRQoL of SM-induced pulmonary complications.[3]

Anti-inflammatory Support

Curcumin has natural anti-inflammatory properties and a series of trials have been undertaken in this field. A study in 2014 evaluated the efficacy of dietary supplementation with a bioavailability-boosted preparation of Curcuminoids in the alleviation of symptoms in patients suffering from knee Osteoarthritis. There was a significant decrease in pain, physical function and stiffness in the control group. The results of this study showed marked improvement in all the assessed efficacy measures therefore it clearly favoured the efficacy of Curcuminoids in alleviating the symptoms and improving the care of patients with OA. Thus it can be said that Curcuminoids represent an effective and safe alternative treatment for Osteoarthritis.[4]

Immune Support

Curcumin has been shown in the last two decades to be a potent immunomodulatory agent that can modulate the activation of T cells, B cells, macrophages, neutrophils, natural killer cells, and dendritic cells. Interestingly also, Curcumin at low doses can also enhance antibody response. A report called "Spicing up" of the immune system by Curcumin [5] suggests that Curcumin's reported beneficial effects in arthritis, allergy, asthma, atherosclerosis, heart disease, Alzheimer's disease, diabetes, and cancer might be due in part to its ability to modulate the immune system.

Another study “Mechanism of immunoprotective effects of Curcumin in DLM-induced thymic apoptosis and altered immunefunction” [6] clearly demonstrates that the mechanism of immunoprotection of Curcumin in DLM-induced thymic apoptosis includes inhibition of oxidative stress and caspase-dependent pathways underlying apoptosis.
There are also many other research areas where Cucurcumin C3 has been used, these include:

  • Colorectal Cancer, Pancreatic Cancer and Anti-Cancer Potentials
  • Immunological Mechanism in Alzheimer's Disease
  • Treatment of Alcoholic Hepatitis
  • Use of Curcuminoids in Cystic Fibrosis
  • Free Radical Trapping Properties of Curcuminoids

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What is Bioperine®?

BioPerine® is an extract obtained from the black pepper fruit which significantly enhances the bioavailability of various supplement nutrients through increased absorption. If a Curcumin or Tumeric supplement does not contain BioPerine® then your body will not be optimising the effects of the active ingredient.

A study from 1998 sought to see the effect of use the Piperine (BioPerine®) enriched black pepper extract on bioavailability of Curcuminoids in the body. The Conclusion was that Piperine (BioPerine®) enhances the oral bioavailability of curcumin in both animals and humans at doses which are devoid of adverse side effects. The bioavailability of curcumin in presence of Piperine (BioPerine®) was enhanced by 2000% in humans. [7]

This graph clearly depicts the enhanced utilization of Curcumin combined with BioPerine®.

Curcumin and Bioperine

Is Curcumin Safe?

In a word, Yes. There is some evidence to suggest it can cause people to experience stomach upset, nausea, dizziness, or diarrhea but this is quite rare. A Study “Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa)” provides a systematic review of the literature was to summarize the literature on the safety and anti-inflammatory activity of curcumin. It concluded that Curcumin has been demonstrated to be safe in six human trials and has demonstrated anti-inflammatory activity. [8]


What is Curcumin C3 Complex®?

Not all Curcumin supplements are made equal. C3 Complex from Love Life Supplements is a specially formulated Curcumin blend. The name C3 Complex has reference to its three main chemical compounds:

  • Curcumin
  • Demethoxycurcumin
  • Bisdemethoxycurcumin

These three ingredients are collectively known as Curcuminoids. It is these 3 compounds that research has shown to offer the greatest range of health benefits. C3 Complex is the first of its kind in a category of nutrients that were described in 1995 as “Bioprotectant”.

Perhaps better understood as a "Super Anti-oxidant" C3 Complex provides optimal protection and integrity to biological systems.[1] Curcumin C3 Complex® has been subject to many clinical trials because it is a trusted and valued resource, many of which are funded by the National Institutes of Health (NIH). This really sets it apart from other Curcumin supplements and provides a host of documented evidence to its health benefits.

So, can Curcumin C3 Complex offer you a happy, healthy and pain free body? It just might! In comparison with other supplements, Curcumin C3 has undergone many clinical trials and, although the effects may differ slightly between individuals, there is very strong evidence to suggest that Curcumin C3 is a bio-protectant offering increased anti-oxidant effect, unrivalled Anti-inflammatory support and great immune enhancement.

At Love Life Supplements we are committed to bringing you the absolute highest quality supplements at the best possible value, and our Curcumin C3 products are no exception. C3 Complex with Bioperine is a solid formula at an incredible price, whilst Curcumin C3 Advanced is our advanced formula with added Vitamin D, tomato and ginger for overall health.
Curcumin C3 complex

References & Further reading

[2](25) Curcuminoids modulate pro-oxidant antioxidant balance but not the immune response to heat shock protein 27 and oxidized LDL in obese Individuals.
Phytother Res 2013; 27(12): 1883-8
[3] 32) Effects of Curcuminoids-Piperine Combination on Systemic Oxidative Stress, Clinical Symptoms and Quality of Life in Subjects with Chronic Pulmonary Complications Due to Sulfur Mustard: A Randomized Controlled Trial.
J Diet Suppl. 2014; DOI:10.3109/19390211.2014.952865
[4] (28) Curcuminoid Treatment for Knee Osteoarthritis: A Randomized Double-Blind Placebo-Controlled Trial.
Phytother Res 2014; doi 10.1002/ptr. 5174
[7] (1) Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers.
Planta Med. 1998; 64(4): 353-6

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