Supplement Industry Daily Briefing: April 03, 2026

Key Takeaways

• FDA Reevaluates Dietary Ingredients: The FDA is reviewing how new ingredients from precision fermentation and cell culture fit within DSHEA, causing industry uncertainty.
• Widespread Potency Failures in Oregano Oil: NOW testing found nearly two-thirds of oregano oil supplements on Amazon failed potency claims, highlighting quality control issues.
• Creatine Gummy Brand Raises $20M: Create Wellness secured $20 million in Series B funding to expand retail distribution and product innovation.
• Multivitamins May Improve Metabolomic Profiles: A 2-year study suggests daily multivitamin supplementation modestly improves metabolomic profiles and may slow biological aging.
• Nu Skin Launches AI Wellness Platform: Nu Skin introduced Prysm iO, an AI-powered device that measures skin carotenoid levels in 15 seconds for personalized nutritional insights.

Top Stories

FDA Reexamines Boundaries of Dietary Ingredients Amid Technological Innovation The FDA is actively reevaluating how new ingredients created through innovative technologies, such as precision fermentation and cell culture, fit within the existing definition of a "dietary substance" under the Dietary Supplement Health and Education Act (DSHEA). This review, prompted by a recent public meeting, is causing uncertainty in the supplement industry, as it could impact the legal status of many new and existing raw ingredients. Industry stakeholders are concerned that a narrow interpretation could stifle innovation and create a "race to market" against pharmaceutical companies. The discussions highlight the pressing need for clearer guidance on the "drug preclusion clause" and the role of technological modifications in ingredient development, signaling a potential modernization of DSHEA to address the growing complexity of the supplement market. [1]

NOW Testing Reveals Widespread Potency Failures in Oregano Oil on Amazon A recent investigation by NOW found significant quality control issues with oregano oil supplements sold on Amazon. Out of 35 products tested, nearly two-thirds failed to meet the potency claims for carvacrol, the primary active ingredient. Alarmingly, six of the tested supplements contained no detectable carvacrol at all. The study highlights the ongoing challenges of ensuring product quality and transparency in the rapidly growing e-commerce supplement market. NOW emphasized the importance of using validated testing methods, such as HPLC, to accurately measure active ingredients and called for greater accountability across the supply chain, from manufacturers to retailers. [2]

Supplement Industry Adapts to Era Without Political Champions The supplement industry is shifting its political strategy in Washington D.C., moving away from relying on a few "political champions" to a broader, more bipartisan approach. Thirty years after DSHEA, the industry's legislative needs have become more nuanced, focusing on technical adjustments rather than major legislative overhauls. The current political climate makes it harder to cultivate champions like the original architects of DSHEA, Senators Hatch and Harkin. Instead, the industry is now focusing on building a wider base of support through the Dietary Supplement Caucus and educating a broader range of legislators on specific issues to ensure continued growth and favorable regulatory conditions. [3]

Business and Investment

Creatine Gummy Specialist Create Wellness Raises $20 Million Create Wellness, a company specializing in creatine monohydrate gummies, has raised $20 million in a Series B funding round led by Alliance Consumer Growth (ACG), along with Impact Capital and existing company investor Unilever Ventures. The funding will be used to expand retail distribution, consumer education, product innovation, and marketing efforts. The company has recently expanded into major retailers like Target, The Vitamin Shoppe, and Sprouts, aiming to make creatine a mainstream wellness product. [4]

Herbalife to Acquire Personalized Supplement Brand Bioniq Herbalife has announced an agreement to acquire personalized supplement company Bioniq, which is backed by Cristiano Ronaldo, for an initial payment of $10 million and a total deal value of up to $55 million. The deal, expected to close in Q2 2026, will be paid out over five years and includes contingent payments based on future performance. The acquisition aims to strengthen Herbalife's personalized wellness platform by integrating Bioniq's patented personalization engine. [5]

Aleos Capital Acquires Majority Stake in Eggnovo Spanish private equity firm Aleos Capital has acquired a majority stake in Eggnovo, a company that produces natural ingredients from eggshell membranes for the nutraceutical, cosmetic, and food industries. This marks the first investment for Aleos Capital's fund. The transaction will allow Eggnovo to accelerate its growth and international expansion plans, highlighting the growing investor interest in sustainable and natural ingredient suppliers. [6]

Science and Research

Multivitamin Supplementation May Modestly Improve Metabolomic Profiles The COcoa Supplement and Multivitamin Outcomes Study (COSMOS) found that daily multivitamin-multimineral (MVM) supplementation, alongside essential minerals like Magnesium Glycinate, may modestly improve metabolomic profiles in older adults. The 2-year study on 399 participants showed increased concentrations of docosahexaenoic acid (DHA) and omega-3 fatty acids, and delayed the increase in creatinine. While not statistically significant after multiple-testing correction, MVM also reduced metabolomic risk scores for 16 chronic diseases and led to a non-significant decrease across all metabolomic aging clocks. [7]

Dose-Response Impact of Geranylgeraniol (GG) Supplementation on Muscle Health A randomized, double-blind, placebo-controlled trial will investigate the effects of geranylgeraniol (GG) supplementation on muscle health in 60 healthy, physically active adults aged 30-60. Participants will receive a placebo, 150mg of GG, or 300mg of GG daily for 8 weeks. The study will measure changes in muscular strength, body composition, and aerobic capacity. The primary endpoints are changes in maximal strength and fat-free mass. This research aims to determine if GG can be an effective supplement for improving physical performance and body composition. [8]

New Product Launches and Formulation

Nu Skin Launches Prysm iO AI-Powered Wellness Platform Nu Skin has launched Prysm iO, a breakthrough intelligent nutritional wellness platform designed to deliver a better understanding of how daily nutrition and supplement routines support overall wellness. The compact, portable device uses advanced skin-scanning technology to noninvasively scan the fingertip and deliver a personalized reading of carotenoid antioxidant levels in just 15 seconds. Built on more than two decades of research, the platform incorporates patent-pending Spectral Rai Technology and a proprietary AI-powered algorithm to provide a personalized "Nutrition Health Score." [9]

InfiniFiber Launches Advanced Synbiotic Fiber Supplement Nootropics Depot has launched InfiniFiber, a 12-ingredient synbiotic system engineered to help close the fiber gap and support gut, metabolic, immune, and overall long-term health, complementing the benefits of a high-quality Multispore Probiotic. InfiniFiber combines eleven distinct fibers with a targeted probiotic to deliver a controlled spectrum of fermentation speeds and short-chain fatty acid production throughout the digestive tract. The product delivers 12 grams of dietary fiber per serving, featuring a 50:50 blend of soluble and insoluble fibers and an optimized 75:25 ratio of fermentable to non-fermentable fiber. [10]

Designs for Health Introduces NeuroCalm Peptide Designs for Health has launched NeuroCalm Peptide, a once-daily capsule designed to support gut-brain axis balance and promote feelings of calm, similar to the stress-relieving benefits of our CALM supplement. The new supplement combines clinically studied peptides and a postbiotic to support emotional well-being and stress resilience, reflecting the growing trend of products targeting the gut-brain connection for mental health support. [11]

Regulations and Quality

Navigating Botanical Regulations: Spotlight on Quality Consistency Industry experts are highlighting the increasing stringency of EU and US regulatory frameworks for botanicals, emphasizing the need for greater transparency, safety, and scientific substantiation. The challenges of ensuring consistent quality at scale due to natural variability in botanicals are significant. Experts stress the importance of strong supplier relationships, robust analytical methods, and supply chain traceability to prevent adulteration and ensure product integrity in the botanical ingredients space. [12]

Biofarma Group Develops Advanced Method for Lactose Detection Biofarma Group has validated a highly sensitive UHPLC-MS/MS analytical method for detecting lactose in food supplements and pharmaceutical products. This advanced method allows for the quantification of lactose at very low levels (below 1 ppm), ensuring the safety and quality of "lactose-free" products for sensitive individuals. The development emphasizes the importance of such methods for quality control, brand credibility, and meeting stringent regulatory requirements in the nutraceutical industry. [13]

Marketing and Consumer Trends

Supplement Industry Sees Big Growth Driven by Everyday Health Needs The supplement industry grew by 5.5% in 2025, reaching $72.9 billion in sales. This growth is driven by consumers increasingly viewing supplements as essential for daily health, rather than a luxury. Key growth categories include sports nutrition, herbs and botanicals, and specialty supplements, with a preference for powder, liquid, and chewable formats. Social commerce, particularly on TikTok Shop, is a major emerging sales channel, fueled by influencer marketing. Additionally, there is a growing consumer demand for transparency and science-backed claims, making third-party verification more important than ever. [14]

Liquid Dietary Supplements Market Projected for Strong Growth The global liquid dietary supplements market is projected to grow from USD 24.68 billion in 2026 to USD 41.10 billion by 2034, at a CAGR of 6.58%. This growth is driven by increasing consumer awareness of micronutrient deficiencies and the rising popularity of "beauty-from-within" supplements. Technological advancements, such as microencapsulation and liposomal technology, are creating new opportunities by improving the stability and bioavailability of liquid supplements. [15]

SupplySide Announces Two New Events Launching in 2027 SupplySide has announced the launch of two new events in 2027: SupplySide Connect Madison and SupplySide Connect Utah. These new tradeshows will deliver networking experiences for professionals in the dietary supplement, food, and beverage industries, bringing the relationship-building opportunities of SupplySide Connect to the Midwest and Mountain West regions. [16]

About the Author

Ben Law is the Founder of Love Life Supplements. He is passionate about health, fitness, and providing high-quality, clean supplements to help people live their best lives. Learn more about Ben's journey and the mission behind LLS at https://www.lovelifesupplements.co.uk/pages/ben-law-founder.

References

1. Nutraceuticals World: Clause E Under the Microscope: FDA Reexamines the Boundaries of Dietary Ingredients
2. Nutritional Outlook: NOW Testing Reveals Potency Failures in Oregano Oil on Amazon
3. SupplySide: Supplement industry adapts to era without political champions
4. Nutraceuticals World: Create Raises $20 Million in Growth Capital
5. Cosmetics Business: Bioniq to be acquired by Herbalife
6. Cuatrecasas: Aleos Capital acquires majority stake in Eggnovo
7. Geroscience: COSMOS multivitamin-multimineral metabolomic profiles study
8. ClinicalTrials.gov: Geranylgeraniol (GG) Supplementation on Muscle Health
9. BusinessWire: Nu Skin Launches Prysm iO
10. Yahoo Finance: InfiniFiber Launches Advanced Fiber Supplement
11. Nutraceuticals World: Designs for Health Introduces NeuroCalm Peptide
12. Nutrition Insight: Navigating botanical regulations
13. Biofarma Group: Advanced Method for Lactose Detection in Supplements
14. New Hope Network: Supplement industry trends: Growth, social commerce and trust
15. Fortune Business Insights: Liquid Dietary Supplements Market Forecast
16. GlobeNewsWire: SupplySide Announces Two New Events Launching in 2027